Zinc is an essential trace element involved in in more than 300 enzymes, supporting crucial bodily functions such as metabolism, digestion, and nerve function. It plays a vital role in the development and function of immune cells, providing protection against oxidative stress and inflammation.

Sambucus nigra, L. (European black elderberry) is a native plant rich in polyphenols and anthocyanins, known for their antioxidant properties. Traditionally used in medicine, elderberries act as diaphoretic, antipyretic, and diuretic agents. They also possess antibacterial and antiviral properties, along with positive effects on cholesterol levels.

Clinical studies have demonstrated the immunomodulatory properties of black elderberry, establishing Sambucus nigra as an effective, natural, over-the-counter alternative to antibiotics and antiviral medications for upper respiratory tract infections.

To address potential symptoms during illness, we’ve included Vitamin B5 (pantothenic acid), known for its contribution to reducing fatigue and exhaustion.

Zinc acetate, in oral spray form, is well absorbed through the oral mucosa, increasing the bioavailability of zinc and inhibiting the replication of rhinoviruses in the nasal and throat mucosa that cause colds. Oral mucosa absorption also enhances the bioavailability of polyphenols from elderberry, particularly anthocyanins. NutriStella oral spray allows you to maximize the benefits of zinc and elderberry for your immune defense.

Vegan. Lactose-, gluten- and GMO-free. Tastes good. Tooth friendly formula (sugar-free). Long lasting. Higher bioavailability and absorption.

Zinc is especially important for healthy growth and development during pregnancy, childhood, and adolescence. Our body stores zinc in cells throughout its tissues, where it contributes to cellular growth, division, and the activity of enzymes, proteins, and DNA. Women typically have around 1.5 grams of zinc in their bodies, while men have approximately 2.5 grams, with the majority stored in our skeletal muscle and bones.

Maintaining zinc balance in the body involves processes such as zinc absorption from our diet, its excretion into the gastrointestinal tract, and reabsorption in the gastrointestinal lumen. As we consume more zinc, the amount absorbed increases, but its fractional absorption decreases.

In clinical settings, healthcare professionals often assess zinc levels through serum or plasma zinc measurements. In healthy individuals, the typical range is 80 to 120 mcg/dL (12 to 18 mcmol/L). Levels below 70 mcg/dL in women and 74 mcg/dL in men may indicate inadequate zinc status. However, these measures have limitations as they can be influenced by factors such as sex, age, and the timing of blood sampling. They may not always accurately reflect dietary or supplemental zinc intake. Additionally, zinc levels can fluctuate due to various factors, such as infections, hormonal changes, and muscle breakdown during weight loss or illness.

According to NHS the amount of zinc you need is about: 9.5mg a day for men (aged 19 to 64 years) 7mg a day for women.

The potentially health-promoting properties of bioactive compounds found in elderberry, especially polyphenols and anthocyanins, have been scientifically investigated. Among the polyphenols found in black elderberry are flavonoids such as proanthocyanidins, chlorogenic acid, and flavonols like rutin, quercetin, kaempferol, and isorhamnetin. Notably, black elderberries are recognized for their high content of another group of polyphenols – anthocyanins, especially cyanidins, which give the berries their dark color.

Anthocyanins are produced by the fruit in response to stress factors such as UV radiation, dryness, or cold temperatures. This protective mechanism helps shield the fruit from DNA damage that could impede proper protein synthesis and cell division. Black elderberries rank among the top three fruits with the highest anthocyanin content – 1374 mg/100 g.

Anthocyanin-rich foods play a crucial role in a healthy diet. Their potential impact on blood pressure, inflammation reduction, and the lowering of the risk of heart disease has been extensively studied in recent years.

Clinical human studies have shown that black elderberry can effectively reduce the duration and severity of symptoms associated with bacterial and viral infections, such as colds and flu.

How does it work?

Three possible mechanisms of action are currently proposed, likely operating concurrently:

  1. Flavonoids bind directly to the spikes of viruses, preventing them from entering host cells to replicate. This effectively prevents, or at least slows, the development of an infection.
  2. Anthocyanins decrease the activity of the virus-promoting enzyme neuraminidase, thereby suppressing virus replication.
  3. Plant polysaccharides – water-soluble fiber contained in ElderCraft® Black Elderberry Extract – stimulate the activity of the body’s own macrophages, which play an important role in the body’s defense system.

IMMUN-KOMPLEX – the power of a unique blend of natural antioxidants: a plant extract from elderberry, rich in concentrated polyphenols and anthocyanins, combined with the benefits of zinc.

For those seeking to fortify their immune system naturally and effectively – supported by centuries of traditional use and robust scientific studies.

Zinc Deficiency

Since our body cannot produce zinc on its own, we need to obtain it through our diet. Inadequate zinc intake in healthy individuals can lead to issues such as hair loss, diarrhea, impotence, eye and skin problems, and loss of appetite. Proper zinc intake is crucial, especially during pregnancy and in children, to support proper healthy growth and development.

Zinc naturally occurs in various food products such as meat, fish, poultry, grains, and dairy products. However, the absorption of zinc can be influenced by the amount of protein in the diet, potentially increasing the vulnerability of vegetarians, vegans, and individuals on restrictive diets to zinc deficiency. Doctors also consider risk factors such as inadequate calorie intake, chronic alcohol consumption, and digestive system diseases that may result in poor absorption of nutrients. They also look for signs of zinc deficiency, such as growth disturbances in infants and children, to assess the zinc levels in their patients.

Zinc Overdose

It’s essential to exercise caution regarding excessive zinc intake, as it can lead to adverse effects such as nausea, vomiting, diarrhea, abdominal cramps, and headaches. Additionally, excessive zinc intake may interfere with the absorption of other essential nutrients like copper, iron, and magnesium.

For zinc supplementation in food supplements, the German Federal Institute for Risk Assessment (BfR) recommends a maximum amount of 6.5 milligrams (mg) per daily recommended intake of a food supplement. According to the NHS, the recommended daily amount of zinc is about 9.5 mg a day for men (aged 19 to 64 years) and 7 mg a day for women. To avoid potential complications, it’s advisable not to exceed the daily recommended zinc intake without medical guidance.

Adults: 4 sprays daily under the tongue or on the inner cheek, providing a daily dose of 6.5mg of zinc (65% NRV*), 100mg of elderberry, and 5.4mg (90% NRV*) of Vitamin B5.

Before the first use, press the pump 2-3 times until the contents appear. Remember to shake before each use and rinse the nozzle with water if congested.

NutriStella Zink+Holunder can be used directly before or after meals. Due to the direct absorption via oral mucosa the impact of food matrix on zinc bioavailability is eliminated.

Zinc Absorption Enhancers:

  • Zinc is best absorbed when taken with a protein-rich meal. The best sources of zinc are oysters (richest source), red meats, poultry, cheese (ricotta, Swiss, gouda), shrimp, crab, and other shellfish
  • Some Polyphenols like Quercetin

Zinc Inhibitors:

    • Foods rich in phytates (e.g., whole grains, cereals, soy, nuts, and legumes).
    • Tannins (e.g., tea, coffee, cocoa, legumes, nuts).
    • Iron
    • Cadmium

INGREDIENTS: Purified water, Elderberry extract (Sambucus nigra L.), zinc (zinc acetate), vitamin B5 (D-pantothenate calcium), natural menthol flavourings, citric acid (acidity regulator),  steviol glycosides (sweetener), natural lemon flavourings, potassium sorbate (preservative)

ElderCraft® European Black Elderberry Extract, present in NutriStella Zink+Holunder, is made from a single component – black elderberry. It constitutes an active blend of natural fruit anthocyanins, polysaccharides, and berry micronutrients, crafted through a unique extraction and ultra-filtration process. The high-quality extract is derived from the finest Haschberg elderberries and is standardized to a high content of anthocyanins and polyphenols. A daily dose of NutriStella Zink-Holunder provides an antioxidant boost with 18 mg of polyphenols and 15 mg of anthocyanins, obtained without chemical additives or solvents such as methanol, butanol, or ethanol. The ElderCraft® elderberries are sourced from controlled organic farms in the Alps.

In NutriStella Zink-Holunder, we adhere to the latest recommendations of the German Federal Institute for Risk Assessment (BfR, 2021) and provide a dose of zinc equivalent to the recommended maximum amount of 6.5 mg per day.

IMMUNITY COMPLEX – Zinc and elderberry extract, combined with Vitamin B5, create the perfect blend for individuals looking to fortify their immunity defenses and strengthen their bodies.

OPTIMAL ZINC DOSAGE – Zinc, an essential trace element crucial for daily bodily functions, supports the immune system and contributes to the normal condition of bones, skin, and nails. Following the recommendations of the German Federal Institute for Risk Assessment, the maximum daily dose for zinc supplements is 6.5 mg.

ELDERBERRY – A highly concentrated (1:64), premium, natural plant extract from elderberries, providing a substantial dose of antioxidants (18 mg polyphenols, 15 mg anthocyanins in 100 mg extract). It supports the immune system and aids in weight management. The effects of zinc and elderberry are enhanced by the addition of Vitamin B5, which contributes to the reduction of fatigue and tiredness.

EXCELLENT ABSORPTION – Administered through the oral mucosa, the preparation allows active ingredients to quickly enter the bloodstream without being destroyed by the digestive system. This results in a significantly higher absorption compared to conventional forms like capsules or syrups. The airless technology bottle protects the product from microbes and degradation, extending its shelf life. Contains 37 daily servings.

CONVENIENT SUPPLEMENTATION WITHOUT UNWANTED ADDITIVES – Easy to use, no swallowing required, no need for breaks between meals, portable, aerosol-free, suitable for air travel. Free from gluten, soy, sugar, glucose syrup, fillers, artificial colors, or flavors in NutriStella’s product. The refreshing taste is provided by natural mint and lemon flavoring. This product is also suitable for vegans and vegetarians.



Zinc plays a pivotal role in regulating the immune response, serving as a key player in controlling infections by modulating inflammatory processes. Scientists have identified specific cells that act as the first line of defense against infections, and zinc interacts with a crucial mechanism in the fight against infections, contributing to a balanced immune response.

A study conducted at Ohio State University emphasized the significance of zinc in preventing excessive inflammation during an infection. Inadequate zinc levels were linked to an uncontrolled immune response. The researchers focused on sepsis, a severe systemic reaction to infection often resulting in fatalities among intensive-care unit patients. Intriguingly, these findings may shed light on why taking zinc supplements at the onset of a common cold seems to alleviate its effects.

In-vitro tests with flu viruses have demonstrated that components present in black elderberry block viral hemagglutination, the mechanism by which flu viruses attach to blood cells. Interestingly, elderberry extracts exhibited a dose-dependent inhibition of a type A flu virus in mammalian cells. Two flavonoids were identified to bind to the virus surface: one, a derivative of dihydromyricetin, and the other, a derivative of quercetin. According to the study authors, the molecular mode of action could involve flavonoids binding directly to the virus particles, preventing their entry into host cells for replication, thereby effectively hindering an infection. The effective concentration required to inhibit virus replication was comparable to that of Tamiflu®, a commonly prescribed drug for treating influenza.

Neuraminidase is an enzyme located on the surface of influenza viruses that enables viruses to be released from their host cell soon after successful replication. During this final stage of virus replication, the release from the host cell needs a cleavage of a sugar bond. Neuraminidases cleave this bond between the virus and host cell, effectively releasing the virus particle into the bloodstream. An Australian research group working with elderberry extracts and viral neuraminidases discovered Cyanidin-3-sambubioside (C3samb) — a major anthocyanin in European black elderberries — can bind to and inhibit the activity of the enzyme neuraminidase of the pandemic type A influenza. The anthocyanin C3samb reduces the activity of viral neuraminidase by binding to its active center and effectively blocking its ability to cleave the sugar bond between the virus and the host cel. This mode of action is effective in suppressing viral replication in-vitro. A common antiviral drug, oseltamivir, has a similar mode of action and is commonly used in the treatment of influenza.

Herbal polysaccharides are a type of water-soluble dietary fiber known to stimulate complementfixing and macrophage activity. Polysaccharides are part of the high molecular weight fraction of botanical extracts and consist of long chains of sugar molecules. The immunostimulatory activity of black elderberry has recently been characterized in a mouse study. The research showed high molecular fractions from elderberry support the mammalian immune system, thereby helping the organism in the fight against viral infections. Mice were infected with a human type A flu virus and fed with a dried elderberry powder. The results showed significantly enhanced local and systemic immune responses. Influenza virus-specific immunoglobulins A and G — antibody-producing proteins that bind to and immobilize pathogens — increased significantly. Virus-neutralizing antibodies also increased significantly in a dose-dependent manner, with mice dosed with elderberry having up to 1.8 times higher concentrations of the antibodies than those in the water-treated control. In an attempt to identify the bioactive components, the researchers fractionated the extract and found that a high molecular weight sub-fraction rich in polysaccharides showed the most overall activity. Interestingly, elderberry had a similar effect as the prescription drug Tamiflu® in reducing the viral yields in lung fluids.


Polysaccharides drive potent immune-modulatory effects

Polysaccharides drive potent immune-modulatory effects

Polysaccharides in IPRONA’s European black elderberry extract ElderCraft® enhance dendritic cell (DC)-mediated T cell immune responses, according to a study published in the International Journal of Molecular Sciences.

The Role of Zinc in Antiviral Immunity

The Role of Zinc in Antiviral Immunity

Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors. (...)

New patent for ElderCraft

New patent for ElderCraft

Black Elderberry extract inhibits the replication of SARS-CoV2 in vitro
A new study of the researchers at the University Erlangen has shown ElderCraft® Black Elderberry Extract has a strong antiviral effect against SARS-CoV-2. Encouraged by the findings, IPRONA has filed to internationally patent ElderCraft® for use in the prevention and treatment of COVID-19.

Zinc Supplementation Increases Zinc Status and Thymopoiesis in Aged Mice

Zinc Supplementation Increases Zinc Status and Thymopoiesis in Aged Mice


Yes. NutriStella Zinc-Elderberry does not contain sugar, glucose syrup, or dextrose. This means that people who are mindful of their blood sugar levels and weight can also use it. With their anti-inflammatory and antibacterial properties, the polyphenols found in elderberries may contribute to dental health.
Elderberries contain high levels of anthocyanins, which give them deep purple color. There are no known reports or studies suggesting that elderberry extract specifically causes teeth staining. While some individuals might experience temporary coloration, similar to what occurs after consuming wild blackberries, maintaining good oral hygiene practices should help eliminate any potential staining.
Yes, because the presence of polyphenols improves the absorption of zinc. Furthermore, administering it through the oral mucosa enhances the effect.
Unlike most syrups, NutriStella Elderberry can be used until the expiration date. The air-free bottle protects the product from oxidation/spoilage and extends its shelf life.
Yes, spraying it on the oral mucosa is very simple, and you can use the spray anytime, regardless of meals. It is also convenient to carry and use it on the go.